Endocrine Abstracts

A 27 year old, Caucasian female was admitted with vomiting and found to have severe hypocalcaemia. On clinical examination she had a normal stature, oval face; she was not brachydactylic and did not have dental hypoplasia. Biochemically she had serum Ca of 1.49 mmol/l (2.15–2.50), a high serum Phosphate of 1.50 mmol/l (0.9–1.45) and Vitamin D levels of 59 nmol/l (>50 sufficient for majority population). Her serum parathyroid hormone was elevated at 304.5 ng/l (15...

Objective: Based on recommendations from the Clinical Practice Guidelines committee group on management of adrenal incidentalomas our project aims to review whether patients found to have adrenal incidentalomas were managed as per recommendations of the committee as follows: If they had a 1 mg overnight dexamethasone suppression test,were they tested for phaeochromocytoma, whether the investigations were used judiciously keeping in view patients co-morbid state, were any of th...

Case History: Mr AT, a 54 year old male was referred by his GP in 2019 with a two year history of raised calcium. He initially sought medical attention for pain radiating from the left buttock to the knee. He had a background of hypertension and pre-diabetes and was on Nifedipine LA 3 mg OD and Furosemide 20 mg OD. He denied headaches, insomnia, concentrating problems, constipation, polyuria and polydipsia. He had no history of fractures nor renal stones. He was a non-smoker a...

A 58 year old male diagnosed with ‘Parkinson's Disease’ in 2016 following symptoms of Parkinsonism and a DaTscan, was admitted with seizures. He was given Benzodiazepines in the A&E which helped control the seizures. A CT scan of his head revealed Bilateral Basal Ganglia calcification. This was the first time he had seizures, but he did complain of having on and off facial twitching and muscle spasms. There was no history of trauma to the head, fevers, or change ...

Case history: A 68 year old woman was referred to Endocrinology with a history of vomiting, extreme fatigue of acute onset and non-specific visual changes. She had a history of primary hypothyroidism and an adenocarcinoma of the lung with bone metastases initially been treated with pemetrexed and cisplatin chemotherapy. The patient subsequently required palliative radiotherapy for metastatic spinal cord compression and was started on denosumab. Imaging shortly before her refer...

Section 1: Case history: At the age of 18 our patient presented with renal stones and was diagnosed with Primary Hyperparathyroidism (PHPT). At 20 she underwent a right sided nephrectomy for a calculus associated non-functioning kidney. Over the years she has had numerous renal calculi, ureteric obstructions with stents, requiring urology input. Of note she had osteoporosis, hypertension, pancreatitis, gastritis, intracranial hypertension (with shunt in situ) and resistant Vit...

Section 1: Case history: 23 Year old Caribbean gentleman attended A&E with several month history of non-specific headaches, changes in memory/mood and joint pains. Since the age of 5 he had been medically treated for renal stones, He had a past medical history of sickle cell trait and was not on any regular medications. There was no significant family history apart from sickle cell disease. He had initial bloods which showed serum adjusted calcium level 3.7 mmol/l and PTH ...

Case history: A 72 year old male was diagnosed with primary lung adenocarcinoma grade T4N2M1b with adrenal and brain metastasis 1 year previously. On diagnosis his tumour was strongly positive for PDL-1 expression. This patient was started on dexamethasone 8 mg once a day that was weaned down to 4mg twice daily and then slowly weaned off steroids whilst receiving whole brain radiation. He was started on pembrolizumab therapy and had received ten cycles of treatment when he beg...